Cole Wayant

I am a dual-degree medical and doctoral student. My dissertation focuses on how bias and methodological/reporting quality affect the oncology literature. I have a particular interest in conflicts of interest, surrogate endpoints in oncology clinical trials, the reproducibility of oncology systematic reviews, and the clarity of oncology clinical practice guidelines. My clinical interests are in hematology/oncology (via internal medicine).

Thus far, I have published in high-impact, reputable journals across many medical specialties such as JAMA, JAMA Oncology, Annals of Oncology, European Urology, British Journal of Anaesthesiology, Laryngoscope, and Chest. My published research has been featured by the New York Times, BMJ, Science, and Nature. In all of my published papers I significantly contributed to the design, methods, analysis, writing, publication, and dissemination. As a result, I have developed expertise in leading research teams and professional, interpersonal communication. I hope to use these skills to mentor future medical students and residents when I work as an academic oncologist.

My wife, Elizabeth, and I stay busy with our newborn son, Ezra. We enjoy talking on our front porch, wine tasting, re-reading books, new and nostalgic music, camping, the perfect cup of coffee, and whatever the other is interested in any given week.


Selected publications

  • Evaluation of the recently proposed P < .005 threshold. JAMA – 2018. PMID: 30398593.
  • Conflicts of interest between oncologists and industry in high-impact drug trials. JAMA Oncology – 2018. PMID: 30178024.
  • Comparison of interim and final analyses in oncology trials. Annals of Oncology - 2018. PMID: 30307531.
  • Selective outcome reporting bias in hematology clinical trials. PLoS One – 2017. PMID: 28570573.

Conflicts of interest

  • Speakers at FDA neurology drug advisory committee meetings. JAMA Neurology - 2018. PMID: 30556837.
  • Viewpoint – Financial conflicts of interest in clinical practice guidelines. BMJ-Evidence Based Medicine – 2018. PMID: 30042209.
  • Urology clinical practice guidelines. European Urology – 2018. PMID: 29747945.


  • Emergency medicine trials. Annals of Emergency Medicine - 2019. Accepted.
  • Otolaryngology trials. Laryngoscope - 2018. PMID: 30578543.
  • Obesity trials. Clinical Obesity - 2018. PMID: 30576083.
  • Anesthesia trials. British Journal of Anaesthesia - 2018. PMID: 30579417.

Methodological/Reporting Quality of Systematic Reviews

  • Pediatric hypertension systematic reviews. Journal of Hypertension – 2018. PMID: 30045363.
  • Reply: Methodological and reporting quality of pediatric hypertension systematic reviews. Journal of Hypertension – 2018. PMID: 30640877.
  • Pediatric obesity systematic reviews. Clinical Obesity – 2017. PMID: 28112500.

Adherence to Reporting Guidelines

  • Oncology journals. BMJ Evidence Based Medicine – 2018. PMID: 29653939.
  • Hematology journals. Journal of Thrombosis and Haemostasis – 2017. PMID: 28122156.
  • Critical care journals. International Journal of Evidence-Based Healthcare – 2018. PMID: 28863029.
  • Emergency medicine journals. Scandinavian Journal of Trauma, Resuscitation, and Emergency Medicine – 2016. PMID: 27881175.

Fragility Index

  • Clinical trials underpinning CHEST guidelines for venous thromboembolism. CHEST – 2018. PMID: 29410171.


  • Strength of evidence in gastroenterology clinical practice guidelines. PLoS One – 2018. PMID: 30281671.
  • Viewpoint – Use of a medical student research team to instill evidence-based medicine principles. BMJ Evidence Based Medicine – 2018. PMID: 30282754.



  • Peer Review Congress, Chicago, IL, USA. September 2017. Methodological and reporting quality of pediatric obesity, n-STEMI, and opioid use disorder systematic reviews. Click for video and abstract.
  • Tulsa Research Day, Tulsa, OK, USA.November 2016. Selective reporting bias in hematology clinical trials.
  • Society for Clinical Trials, Montreal, Quebec, CA. May 2016. Publication bias in oncology systematic reviews. (Presented on behalf of David Herrmann, lead author).


Number to date: 19